Selected Publications & Invited Talks
Video
"Video Compression," in The Handbook of Computer Networks (Hossein Bidgoli, ed.), pub:John Wiley & Sons, Inc.
"Video," in The Encyclopedia of Human-Computer Interaction (William Sims Bainbridge, ed.), pub:Berkshire Publishing Group, LLC.
"Video Compression," in The Internet Encyclopedia (Hossein Bidgoli, ed.), pub:John Wiley & Sons, Inc.
Pharmacometrics
Freedman, I. (2019), "Chaos Synchronization: Identifying & Predicting Noisy Complex Systems," in AAPS Forum to Connect Predictive Modelers, May 6-7, 2019 Boston MA
Pillai, N. et al. (2019), "Estimating Parameters of Nonlinear Dynamic Systems in Pharmacology using Chaos Synchronization and Grid Search", JPKPD
van Oordt, C. W. M. H et al. (2019), "ImmunoPET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" , J Nucl Med jnumed.118.214726 published ahead of print February 7, 2019
Norris, D. et al. (2018), “Expansion Cohorts: Use in First-In-Human Clinical Trials To Expedite Development of Oncology,” submitted to FDA, FDA-2018-D-2777-0001, DOI 10.17605/OSF.IO/NMGH8
Freedman, I. (2018), “IEEE Digital Health Standards,” at FIS Global , November 27, 2018, Collegeville:PA
Freedman, I. (2018), “Chaos Synchronization: Estimating Parameters of Noisy Complex Systems,” in IEEE Section Night, October 20, 2018, Philadelphia:PA
Schieke, M. & Freedman, I. (2018), “3D Topological Mapping of Macroanatomy and Microanatomy for Use in Big Data and Augmented Intelligence Systems,” in IEEE-Standard Association Workshop on Digital Health Standards, September 11, 2018, Atlanta:GA
Pillai, N. et al. (2018), "Chaos synchronization and Nelder-Mead search for parameter estimation in nonlinear pharmacological systems: estimating tumor antigenicity in a model of immunotherapy," PBMB Special Issue Volume 139, November 2018, Pages 23-30
Pillai, N. et al. (2018), "Estimating parameters of chaotic systems: chaos synchronization combined with Nelder-Mead search, " in PAGE 2018: May 31, 2018, Montreux CH
O'Connor, M. A. et al. (2017), "Elucidating Exposure-Response (Safety and Efficacy) of Adct-402 (Loncastuximab Tesirine), a Novel Pyrrolobenzodiazepine-Containing Antibody Drug Conjugate, for Recommended Phase 2 Dose Determination in Patients with Relapsed or Refractory Non-Hodgkin Lymphoma," in American Society of Hematology 59th Annual Meeting & Exposition, Atlanta GA Dec 9-12, 2017
Freedman, I., Bies, R. R., Pillai, N., Schwartz, S., Ho, T. (2017), "Estimating parameters of chaotic systems in pharmacology", invited talk in American Conference on Pharmacometrics 8, Oct 14-19, 2017, Ft. Lauderdale:FL
McGeoch, A.C. et al. (2017), "ImmunoPET imaging to assess target engagement: Experience from 89Zr-anti-HER3 mAb (GSK2849330) in patients with solid tumors" in Annual Congress of the European Association of Nuclear Medicine, Oct 21-25, 2017, Vienna:AT
"Pharmaco-Imaging in Translational Science and Research," in Pharmaco-Imaging in Drug and Biologics Development, (Brian R. Moyer, Narayan P. S. Cheruvu & Tom Hu, eds.), pub: AAPS/Springer
Nguyen, T-H-H. et al. (2016), Model evaluation of continuous data pharmacometric models: metrics and graphics, CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):87-109
Freedman, I., Bies, R. R. & Pillai, N. (2016), "Estimating parameters of chaotic systems," invited speaker, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, November 13-17, 2016, Denver:CO
Freedman, I. (2015), “Imaging & Microdialysis: Complementary Modalities?” invited panelist, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, October 24-29, 2015, Orlando:FL
Bies, R. R., Ho, T. & Freedman, I. (2015), “Nonlinear dynamic physiological systems: Chaos Synchronization as an approach to parameter estimation” in Kinetic and Dynamic Complexity in Drug Transit-Response in the Human Body, satellite meeting to Population Approach Group Europe 2015, June 2, 2015, Hersonissos:GR
Freedman, I. (2015), “Model Evaluation and Selection,” invited talk to American Association of Pharmaceutical Sciences Pharmacometrics Focus Group, March 26, 2015
Freedman, I., Moyer, B.R & Cheruvu, N.P.S. (2014), “Pharmaco-Imaging”, in American Association of Pharmaceutical Sciences Translational Sciences 101 e-learning course, retrieved from http://www.aaps.org/TS101/
Freedman, I. (2014), “Role of Pharmacology in Anti-Cancer Antibody Development,” invited talk, in American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Nov 2-6, San Diego:CA
Austin, D., Freedman, I., Grove, R, Tolson, J. & Vanmeter, S. (2014), "The Relationship Between Peripheral B-Cell Levels and MRI Disease Activity in Relapsing-Remitting Multiple Sclerosis (RRMS)", dual presentation in American Academy of Neurology 66th Annual Meeting, Philadelphia:PA
Freedman, I. & Bies, R. (2013),"Chaos Synchronization," invited talk, in 3rd Annual Indiana Clinical and Translational Sciences Institute Symposium on Disease and Therapeutic Response Modeling, Nov 5-6, 2013, Indianapolis, IN
Freedman, I. (2013), “Translational pharmacometric models of anti-cancer antibodies,” invited talk, in 2nd International Conference on Translational & Personalized Medicine, Aug 5-7, 2013, Chicago IL
Freedman, I. (2012), “Case Studies in the Use of Imaging Agents in Proof-of-Concept and Early Proof-of-Efficacy Trials,” invited talk, in National Biotechnology Conference, May 21-24, 2012, San Diego:CA
Freedman, I. (2012), “Regulatory Opportunities and Hurdles with Imaging Agents in the Era of Personalized Medicine,” invited panelist, in National Biotechnology Conference, May 21-24, 2012, San Diego:CA
Freedman, I. (2012), “Translating Clinical and Pre-Clinical Information into Success,” invited talk, in 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA
Freedman, I. (2012), “Improving Integration of PK/PD Modeling into the Drug Development Process,” invited panelist, in 3rd World PK/PD Summit, March 27-29, 2012, Boston:MA
Freedman, I. (2011), “The Impact of 3D Tissue Models on Drug Development and Predictive Safety,” invited panelist, in Predictive Functional Tissue Models, November 17-18, 2011, Boston:MA
Freedman, I. (2011), “Case Study–Optimizing Design of a Phase 2 Clinical Trial in Relapsing-Remitting Multiple Sclerosis,” invited talk, in Joint Statistical Meetings 2011, Miami FL July 30-August 4, 2011
Freedman, I. (2011), “Case Study–Bridging from Western to East Asian Population in Accordance with ICH E5,” in American Conference on Pharmacometrics 2011, San Diego CA April 3-6, 2011
Freedman, I et al. (2009), “Bayesian Parametric Schild Analysis from a Whole Blood Stimulation Assay,” in American Conference on Pharmacometrics 2009, Mystic CT October 4-7, 2009
Freedman, I. (2009), “Feasibility of Immunogenicity Assessment based on Models of Polyclonal Anti-Drug Antibody Immunodynamics,” in American Conference on Pharmacometrics 2009, Mystic CT October 4-7, 2009
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